Our Science

Real Research.
Real Results.

At Lilli Health, our approach isn’t based on trends, it’s built on science. A Low Insulin Lifestyle is backed by over a decade of clinical research, showing how targeted lifestyle changes can lower insulin levels, improve metabolic health, and transform lives. On this page, you’ll find real-world outcomes from our patients, an overview of our clinical studies, and links to published research. From weight loss and improved insulin sensitivity to hormonal balance and fertility breakthroughs, the science speaks for itself.

Weight Loss

Our PILOT study showed an average loss of 19 lbs in 8 weeks. Below that, an independently conducted RCT compared standard PCOS recommendations to a Low Insulin Lifestyle delivered either in-person or virtually. This tested the scalability of our approach—even during the COVID-19 pandemic when weight gain was common.

Insulin Reduction

This image shows fasting insulin, 2-hour insulin from an oral glucose tolerance test, and HOMA-IR scores before and after following a Low Insulin Lifestyle. Across our pilot and metabolic studies, insulin dropped by over 50%, with dramatic improvements in insulin sensitivity in just 8 weeks.

A1c Improvement

While participants began with normal A1c values (5.5%), we still saw a significant improvement to 5.2% in just 8 weeks. Since A1c reflects a 3-month average of blood sugar levels, seeing this much of a drop in less than 2 months is an incredibly strong result and highlights how powerful this approach can be.

Testosterone

Free testosterone dropped by 23% in our studies—more than what you would typically see with medications like spironolactone—while patients also experienced improvements in acne and excess hair growth.

Symptom Relief

Patients reported major improvements in energy, bloating, acne, cycle regularity, and other PCOS-related symptoms. These were measured using the validated PCOS Quality of Life (PCOS-QOL) Questionnaire. We also saw a notable drop in binge eating behavior.

Fertility

In a case series, women previously diagnosed as infertile and obese conceived within an average of 86 days on a Low Insulin Lifestyle—without using fertility medication.

Research Timeline

PILOT Study

Our first study in 24 patients showed average weight loss of 19 lbs in only 8 weeks with a 52% reduction in fasting insulin and more than 50% drop in HOMA-IR.

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METABOLIC Study

This study demonstrated a dramatic increase in fat oxidation due to a 52% reduction in fasting insulin levels.

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Randomized Controlled Trial (RCT)

This independent RCT revealed significant reductions in weight, BMI, and waist circumference across both video education and face-to-face groups.

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Case Series

An independent case series found that a Low Insulin Lifestyle improved menstrual regularity and led to conception within an average of 86 days in previously infertile women with obesity—without the use of fertility medications.

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