We love to obsess over long-lived cultures.
Every wellness article, Netflix doc, and influencer seems to be talking about Blue Zones—those magical places in the world where people supposedly live forever while sipping bone broth and eating purple sweet potatoes.
And don’t get me wrong—there’s some value in looking at lifestyle patterns. But can we all take a deep breath and talk about something no one seems to be saying out loud?
It’s not the sweet potatoes.
It’s not the seaweed.
It’s not the Tai Chi.
It’s their genetics.
And more importantly—when it comes to aging and longevity, the three biggest players are:
- Insulin
- IGF-1 (Insulin-like Growth Factor 1)
- mTOR (mechanistic target of rapamycin, a key growth pathway)
These three control how fast you age, how often your cells repair (or don’t), and how much wear and tear your body accumulates over time. The longer these systems stay calm and balanced, the slower you age.
So instead of obsessing over what these long-lived cultures eat (or don’t)… let’s talk about what IGF-1 and mTOR actually do.
What Are IGF-1 and mTOR?
IGF-1 is a hormone that helps your body grow and repair. It’s stimulated by insulin and protein intake, especially animal protein and dairy. While it’s great for building and healing, chronically high IGF-1 levels are linked to cancer, cysts, and accelerated aging. It’s not about avoiding it completely—just keeping it in check.
mTOR is a potent growth pathway that tells your cells to build, divide, and multiply. It’s triggered by insulin, excess calories, and BCAAs (branched-chain amino acids found in high amounts in animal protein and dairy). Even if you’re trying to build muscle, you don’t want mTOR turned on all the time. You want it activated strategically—like during recovery or after a workout. But when it’s constantly switched on, day in and day out—especially from things like drinking whey protein shakes or overloading on high-BCAA foods—that’s when aging accelerates and your risk for disease starts climbing. More mTOR activation isn’t better. It’s about timing and balance.
You want IGF-1 to be high during infancy and puberty—those are your major growth phases. After that, levels should naturally decline through adulthood to support repair over growth. Then, in older age, a slight increase can actually help preserve muscle mass and strength. It’s all about the right amount at the right time.
Bottom line: For young and middle-aged adults, we need IGF-1 and mTOR—but not all day, every day. The key to longevity is knowing how to cycle between growth and repair—not being stuck in growth mode forever.
And that’s exactly what makes some of the world’s longest-living populations so interesting.
Let’s Start with Japan
The Japanese population has some of the lowest insulin secretion capacity in the world. Their pancreas simply cannot pump out insulin like ours does—and it literally can’t keep up with their starch-heavy diets.
This is a genetic trait, and it’s also why type 2 diabetes hits them fast and hard. When your body doesn’t make enough insulin, your blood sugar rises. And since insulin is your fat storage hormone, people with low insulin levels tend to be thin. That’s why being “skinny and diabetic” is actually very common in East Asian countries. Yes, you can be thin and still have type 2 diabetes if your pancreas can’t keep up with the demands of a high-starch diet.
But guess what else comes with having naturally low insulin?
- Lower IGF-1 levels (which is also why they tend to be shorter in stature)
- Less activation of mTOR (the pathway tied to cellular growth and aging)
- Slower cellular aging (aka why they often have that glowing, ageless skin)
So no, it’s not the purple potatoes. It’s not the rice. It’s not magic. It’s their genetics.
So yes, they age slower—not because they eat seaweed, but because their hormonal pathways for growth and aging are naturally downregulated.
You’re not going to magically become long-lived by copying someone else’s rice-heavy meal plan if your genetics and metabolism are totally different.
The Loma Linda Vegan Factor
Then we look at another popular Blue Zone: Loma Linda, California—known for plant-based diets, long lifespans, and regular fasting.
People love to point out that these folks are mostly vegetarian or vegan, and that cutting out animal protein must be the key to longevity.
But let’s break this down.
It’s not just about plants. It’s about protein type and its effect on insulin and growth pathways:
- Animal proteins, especially dairy, are high in BCAAs (branched-chain amino acids).
- BCAAs stimulate insulin, IGF-1, and mTOR—aka the growth and aging pathways.
- These are helpful during development (think babies and puberty)… but staying in “grow” mode forever? Not ideal for longevity.
That doesn’t mean you need to go full vegan. You just need to balance your intake:
- Mix animal and plant proteins
- Prioritize non-starchy plant proteins (like nuts, seeds, hemp, edamame, and lupini beans)
- Skip the whey and casein protein powders—those are designed to grow a baby calf, not adults
What About Laron’s Syndrome?
If you really want to understand longevity, look at people with Laron’s Syndrome—a rare genetic condition where the body doesn’t produce IGF-1.
These individuals have near-zero cancer rates. They also tend to live long lives. And it’s not because they follow a plant-based, organic, gluten-free, or adaptogenic diet. It’s because they have genetically low IGF-1 levels, which protects their cells from overgrowth and mutation.
And guess what? Individuals with Laron syndrome DNA are primarily found in the Mediterranean, parts of Asia, and Jewish ancestry—some of the exact same regions and ancestry highlighted in Blue Zone research. The largest studied population with Laron syndrome is in Ecuador, but the mutation has also been identified in populations from the Mediterranean. So before we rush to copy their diets, it’s worth asking: how much of their health and longevity is about lifestyle—and how much is baked into their DNA?
It’s the same principle: less insulin, less IGF-1, less mTOR… less aging.
So Can We Chill on the Blue Zones Hype?
The problem with the Blue Zone obsession is that it turns into a weird nutritional cosplay. People try to mimic Okinawan breakfasts or go vegan for longevity without ever asking the most important question:
Do I have the same metabolism or genetics as these people?
If your ancestors were storing fat through long winters and surviving famine, your insulin response is probably very different from someone whose ancestors lived on fish and rice. You can’t override your metabolic history by eating purple sweet potatoes three times a day.
Eat for YOUR Metabolism, Not Theirs
Here’s the bottom line:
- People in long-lived cultures tend to have lower insulin secretion and lower IGF-1 levels—either genetically or due to lifestyle habits.
- They don’t snack all day, they’re not guzzling protein shakes, and they aren’t constantly triggering growth hormones.
- You don’t need to eat exactly like them—but you do need to understand what actually drives aging: chronically elevated insulin, IGF-1, and mTOR.
So instead of trying to become someone else’s version of “healthy,” ask:
- How can I eat in a way that works with my metabolism?
- How can I keep insulin and growth pathways in check?
- How can I build meals that support repair, but not constant growth?
Because longevity isn’t about copying someone else’s diet. It’s about understanding how someone with your metabolism ages—and working with it, not against it. In the end, if you want to live longer, it starts with lowering your insulin levels.
References
Vitale G, et al. Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians’ offspring. Aging (Albany NY). 2012. Read more
Perice L, et al. Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function. Aging (Albany NY). 2016. Read more
Milman S, et al. Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell. 2014. Read more
Romo Ventura E, et al. Association of dietary intake of milk and dairy products with blood concentrations of insulin-like growth factor 1 (IGF-1) in Bavarian adults. Eur J Nutr. 2020. Read more
Michaëlsson K, et al. Milk intake and risk of mortality and fractures in women and men: cohort studies. BMJ. 2014. Read more
Laron Syndrome. Read more