Category Archives: PCOS

PCOS is often associated with irregular cycles, infertility, and insulin resistance, but one of the most overlooked aspects of PCOS is chronic inflammation. Inflammation plays a central role in PCOS, contributing to hormonal imbalances, metabolic dysfunction, and long-term health risks.

Understanding what drives inflammation in PCOS and how to manage it can make a significant difference in symptoms and overall well-being.

What Causes Chronic Inflammation in PCOS?

Inflammation is the body’s natural response to injury or infection, but in PCOS, the immune system remains in a low-grade inflammatory state even when no infection is present. Several factors contribute to this:

• Insulin Resistance: High insulin levels trigger the release of inflammatory markers like C-reactive protein (CRP) and cytokines, worsening inflammation and metabolic dysfunction.
• Excess Androgens: Elevated testosterone and other androgens promote inflammation and disrupt immune system regulation.
• Visceral Fat: PCOS often leads to fat storage around the abdomen, which releases inflammatory molecules that increase insulin resistance and hormone imbalances.
• Oxidative Stress: Increased levels of oxidative stress in PCOS lead to damage at the cellular level, fueling inflammation and worsening symptoms.

Gut Health Disruptions: Cause or Effect?

There is a growing discussion around the role of gut health in insulin resistance. Some suggest that an imbalanced gut microbiome may drive metabolic dysfunction, but the reality is more complex. The real problem is chronic inflammation caused by insulin resistance, which disrupts gut bacteria, not the other way around.

When insulin levels remain elevated, it creates a pro-inflammatory environment that alters gut permeability, damages beneficial bacteria, and allows harmful bacteria to thrive. This can further contribute to digestive issues and systemic inflammation. However, taking a probiotic alone will not fix the problem—lowering insulin levels and reducing inflammation is the key to restoring gut health.

Effects of Chronic Inflammation in PCOS

Persistent inflammation does not just contribute to PCOS symptoms—it also increases the risk of long-term health issues.

• Worsening Insulin Resistance: Inflammation makes insulin resistance more severe, leading to higher insulin levels and worsening metabolic health.
• Hormonal Imbalances: Chronic inflammation disrupts ovarian function, leading to irregular cycles, increased androgens, and difficulty with ovulation.
• Weight Gain and Fatigue: Inflammatory signals interfere with metabolism, making it harder to lose weight and contributing to persistent fatigue.
• Increased Cardiovascular Risk: PCOS already raises the risk of heart disease, and chronic inflammation further damages blood vessels, increasing the likelihood of hypertension and arterial plaque buildup.
• Fertility Challenges: Inflammation affects egg quality, implantation, and overall reproductive function, making it harder to conceive.

Managing Inflammation in PCOS

Reducing inflammation is key to improving symptoms and protecting long-term health. Here are the most effective ways to manage it:

1. Lower Insulin Levels: Since insulin resistance is a major driver of inflammation, keeping insulin levels stable is one of the most powerful ways to reduce inflammation. Avoiding insulin-spiking foods can help lower inflammatory markers and improve overall metabolic health.

2. Prioritize Anti-Inflammatory Foods: Focusing on whole, nutrient-dense foods that fight inflammation can make a big difference. Key choices include:

• Omega-3-rich foods like salmon, sardines, and flaxseeds
• Leafy greens and colorful vegetables high in antioxidants
• Nuts and seeds for healthy fats
• Olive oil and avocado for anti-inflammatory monounsaturated fats

3. Get Regular Movement: Exercise lowers inflammation and improves insulin sensitivity. Strength training and walking are particularly beneficial for reducing inflammatory markers while improving metabolic function.

4. Address Gut Health the Right Way: Instead of relying on probiotics as a quick fix, focus on the real issue: insulin resistance. Once insulin levels are under control, gut health can naturally improve.

5. Manage Stress and Prioritize Sleep: Chronic stress raises cortisol, which drives inflammation. Mindfulness, deep breathing, and getting at least seven hours of sleep per night can help regulate stress hormones and lower inflammation.

The Bottom Line

Chronic inflammation is a major driver of PCOS symptoms and long-term health risks. While gut health plays a role, the real issue stems from insulin resistance fueling inflammation—not the other way around. Probiotics alone will not fix the problem, but lowering insulin levels through A Low Insulin Lifestyle can reduce inflammation, improve gut health, and restore hormonal balance.

If you are looking for an easy way to track your metabolic health, Lilli Metabolic Testing Kits can help you measure your insulin levels and take control of your PCOS journey.

References:

• Patra D, Banerjee D, Ramprasad P, Roy S, Pal D, Dasgupta S. Recent insights of obesity-induced gut and adipose tissue dysbiosis in type 2 diabetes. Front Mol Biosci. 2023. Read more
• Duca FA, Lam TK. Gut microbiota, nutrient sensing and energy balance. Diabetes Obes Metab. 2014. Read more

Around the globe, Polycystic Ovary Syndrome (PCOS) is a shared reality for 1 in 5 women. If you’ve been diagnosed with PCOS, you’re likely grappling with the challenging duo of weight gain and insulin resistance, thanks to high insulin levels.   

Healthcare professionals often suggest weight loss to manage insulin levels, a solution that seems straightforward. However, high insulin levels can make this mission feel like an uphill battle in a snowstorm. A more effective strategy understands the interplay between insulin and exercise for PCOS. This article explores why specific exercises are ideal for PCOS and how they tie into a holistic, sustainable lifestyle for improving symptoms and achieving long-term goals. Let’s get started!  

Understanding Exercise and PCOS  

Exercise is universally recognized for its many benefits, such as improved overall fitness, better sleep, stress reduction, and weight loss. However, for women with PCOS, the benefits go even deeper. Exercise aids in reducing insulin levels, promoting weight loss, and, more importantly, helping manage PCOS symptoms. 

The goal of exercising for PCOS isn’t merely to burn calories; it’s to purge excess insulin from your blood and make the insulin your pancreas secretes work better. 

So, how does this work? Exercises that focus on lowering cortisol levels and clearing excess glucose from the blood are the most effective.  

Cortisol, the “stress hormone,” is produced by your adrenal glands in response to stress. Chronically high cortisol levels can lead to higher insulin levels, which can increase androgen production from the adrenal glands and ovaries, resulting in PCOS signs and symptoms.  

Choosing the Right Exercises to Lower Insulin Levels  

If calorie burning isn’t the main objective, what exercises should you choose for managing PCOS?   

Research suggests walking, strength training, short bursts of high-intensity interval training (HIIT), and low-impact exercises like yoga are ideal for lowering insulin levels and reversing insulin resistance.  

Walking   

Simply getting your steps in every day can be incredibly beneficial for PCOS! Walking reduces cortisol levels, lowers insulin levels, and mitigates inflammation. On the contrary, more intense activities like running can elevate cortisol levels, potentially leading to increased insulin and androgen production. Therefore, walking proves more beneficial than general cardio for managing PCOS symptoms, including weight gain.  

Strength Training

Strength training activities, like lifting weights or squats, lower insulin levels by activating GLUT-4 vesicles, which shuttle glucose into the cells. This process reduces the amount of insulin secreted by your pancreas and improves your body’s sensitivity to insulin. Regular strength training, regardless of how heavy the weights are or how much muscle mass you build, is extremely helpful in lowering insulin levels.  

High Intensity Interval Training (HIIT)   

HIIT exercises are short, intense workouts followed by rest intervals. An example is sprinting, with a short rest period between each sprint. These exercises can be done in just 10 minutes and have been shown to be very effective at helping reverse insulin resistance. Despite causing a brief increase in cortisol levels, they help lower insulin levels and improve insulin sensitivity. However, for HIIT to be effective, it must be paired with a low-insulin lifestyle.  

Low-impact Exercise  

Activities such as yoga, barre, Pilates, and tai chi, help lower cortisol and clear excess insulin from the blood. They help connect breathing, movement, and meditation, which are known to be effective at lowering cortisol levels. Despite not being major calorie burners, these activities are among the best for improving insulin sensitivity.  

High-Intensity vs. Low-Intensity: Which Is Better?  

When it comes to managing PCOS, both high-intensity and low-intensity exercises can be part of an effective fitness strategy. But it’s essential to understand how each type impacts insulin levels and, consequently, PCOS symptoms.  

High-Intensity Exercise  

For women with PCOS, high-intensity exercises have been shown to help reduce insulin resistance effectively. The intense activity pushes your muscles to work harder, allowing them to absorb more glucose from your blood, reducing the amount of insulin required. This mechanism helps lower insulin levels in your bloodstream, improving your body’s sensitivity to insulin, a crucial factor for weight loss and managing PCOS.  

Low-Intensity Exercise  

Low-intensity exercises such as walking, yoga, Pilates, and strength training involve sustained activity at a steady pace. These exercises are less about burning calories and more about maintaining steady blood glucose levels, reducing insulin spikes, and managing cortisol levels.  

Finding a Balance  

The best fitness strategy for managing PCOS is a balanced combination of high-intensity and low-intensity workouts tailored to your needs and preferences. Experiment with different exercises, pay attention to how your body responds and adjust your routine accordingly. The goal should be a consistent, sustainable fitness regimen that works for you and supports your journey to manage PCOS.  

Is Exercising the Key to PCOS Weight Loss?  

While exercise is part of the weight loss equation, nutrition is the main element. Simply put, you can’t out-exercise a poor diet. If your food intake consistently spikes your insulin levels, no amount of exercise will compensate.   

A combination of regular exercise and a low-insulin lifestyle – eating foods that minimize insulin spikes – can increase insulin sensitivity and remove excess insulin from the bloodstream. This approach can help lower insulin levels, reduce testosterone production, improve PCOS symptoms, and aid in weight loss.  

Final Thoughts: Losing Weight with PCOS  

Remember, be physically active because it’s beneficial for your body. It reduces stress, lowers insulin levels, and can improve sleep. Choose activities that bring you joy, irrespective of their calorie-burning capacity. A sustainable lifestyle change is crucial for managing PCOS, and that’s where Lilli Health can help.  

About Lilli Health  

At Lilli Health, we’re committed to dispelling the fog of misinformation surrounding PCOS treatment and management. We provide science-backed strategies to help you overcome PCOS symptoms and achieve long-term wellness goals.   

From weight loss and improving fertility to taming inflammation, we’ve got your back with a toolkit designed to help you succeed. For more evidence-based strategies, grab our book, “Low Insulin Lifestyle,” and subscribe to our newsletters for PCOS-related content delivered straight to your inbox!   

With a low-insulin lifestyle and the right fitness tips, you can effectively manage PCOS. Remember, no amount of exercise alone can lead to effective weight loss without sustainable lifestyle changes, and we’re here to guide you along the way.   

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Exercise for PCOS FAQs  

Can exercise help with my insulin resistance linked to PCOS?  

• Yes, exercise can certainly help with insulin resistance linked to PCOS. Both aerobic exercises, such as walking and resistance training, promote glucose uptake in your cells, effectively reducing insulin levels in your blood. Lower insulin levels can alleviate insulin resistance, a common symptom in women with PCOS.  

Will exercise help with weight loss if I have PCOS?   

• Yes, exercise can assist with weight loss if you have PCOS, but not in the traditional sense of “calories in, calories out.” The key lies in the type of exercise and how it impacts insulin levels. Remember, weight loss in PCOS is less about calorie burn and more about reducing high insulin levels. Activities that help lower insulin levels, such as walking, strength training, HIIT, and low-impact exercises like yoga, can contribute to weight loss.  

Can regular exercise help regulate my menstrual cycle?   

• When combined with a low-insulin diet, regular exercise can help regulate menstrual cycles. By helping reduce insulin levels and testosterone levels, exercise can help restore ovulation and regular menstrual cycles in women with PCOS. It’s important, however, to avoid excessive exercise, which can stress the body and potentially disrupt the menstrual cycle.    

Can exercise help alleviate symptoms such as fatigue, mood swings, and depression associated with PCOS?   

• Yes, exercise can play a significant role in managing these symptoms. Regular physical activity boosts mood and can help reduce fatigue by improving energy levels. Additionally, certain exercises like yoga and Pilates can help manage stress and alleviate mood swings. Exercise can also have a positive impact on depression, acting as a natural antidepressant by triggering the release of endorphins, the body’s feel-good hormones.  

Polycystic Ovary Syndrome (PCOS) can seem like a complex puzzle, with each piece intricately linked to another. A crucial piece in this puzzle is insulin resistance. If this term is new to you, you’re not alone. 

The role of insulin is one of the most overlooked aspects of managing and treating patients with PCOS, but perhaps one of the most important. Understanding its implications on your body and its connection to PCOS symptoms is crucial for managing your condition, losing weight, and attaining sustainable wellness. This blog will delve into insulin resistance and its impact on PCOS symptoms. Read on for everything you need to know!

What Is Insulin Resistance? 

Insulin resistance is a condition in which your body’s cells become less responsive to insulin, a hormone that helps regulate blood sugar. This means your body needs to produce more insulin to get the same effect, resulting in even higher insulin levels in the blood.   

When insulin levels remain elevated for extended periods, typically as a result of eating a diet that causes recurrent insulin spikes, your body’s response to insulin begins to taper off. It’s like knocking louder on a door when no one answers, except the door is your cells, and the knock is insulin. This phenomenon is insulin resistance, where cells are resistant to the insulin the pancreas secretes.   

Insulin Resistance: The Hidden Link to PCOS   

Women with PCOS tend to have the highest insulin levels among any population. This means that PCOS and insulin resistance are tightly entwined. High insulin levels trigger your ovaries to overproduce testosterone, a hormone associated with several PCOS symptoms, including acne, irregular periods, and excessive hair growth.  

Simply put, high testosterone levels, triggered by high insulin levels, are what you can thank for all the pesky signs and symptoms of PCOS!  

Testosterone and PCOS: An Unwanted Alliance   

Excessive testosterone can set off a series of chain reactions leading to common PCOS symptoms. For instance, it activates sebaceous glands, leading to increased oil production and clogged pores, which cause acne. Similarly, heightened testosterone levels can stimulate hair follicles on the face, chest, and lower abdomen, resulting in hirsutism or unwanted hair growth.   

Insulin Resistance and PCOS: Affecting Ovulation and Weight   

Insulin resistance in PCOS can profoundly impact menstrual cycles and body weight. Elevated insulin and testosterone levels disrupt ovulation, often leading to infertility in women with PCOS.   

High insulin levels can also increase your appetite and create cravings for sugary and carb-rich foods. Remember, high insulin levels mean you can’t burn stored body fat for energy. To compensate, your body slows down its metabolism and makes you hungry, so you’ll eat more food.  

It needs that extra food to help provide energy because it can’t access your stored body fat. In turn, this worsens the cycle and drives insulin levels even higher. Coupled with testosterone-induced impulsivity and increased hunger, it creates the perfect storm for weight gain – a common PCOS sign and indicator.   

 

Identifying Insulin Resistance   

Given that nearly 9 out of 10 US adults have some level of insulin resistance, it’s essential to identify this condition early on. However, measuring insulin levels is rare among healthcare providers, making detection challenging.   

Common symptoms such as frequent cravings for sweets, fatigue after meals, brain fog, and difficulty losing weight might indicate insulin resistance. If you experience these symptoms, we recommend you consult a healthcare professional and ask for an insulin level test. But you should be prepared that they may say no. Luckily, Lilli Health will be launching At-Home Insulin Testing Kits soon to help you monitor your insulin levels and gain critical insights into your overall health! 

What Foods Cause Insulin Spikes?   

While all foods cause an insulin spike to some extent, certain types cause higher spikes than others. Foods rich in whey proteins, starches, and carbohydrates tend to cause the highest insulin spikes compared to non-starchy vegetables, fruits, and lean meats. Regular consumption of insulin-spiking foods over time can lead to long-term health complications, including insulin resistance.   

“A diet that causes recurrent insulin spikes leads to insulin resistance, and insulin resistance leads to weight gain and even higher levels of insulin. This is the premise behind Lilli Health and a low insulin lifestyle. Preventing diet-induced spikes in insulin by following a low insulin lifestyle is the first step in reversing this vicious cycle.” – Low Insulin Lifestyle: My personal journey with PCOS and the science behind a low insulin lifestyle by Ali Chappell.  

Can I Reverse Insulin Resistance?   

Here’s the good news: you can manage and even reverse insulin resistance by following a low insulin lifestyle. Simply eating foods that don’t spike insulin is all it takes!   

Your body will become more sensitive to the insulin it secretes, thereby lowering insulin levels and reversing insulin resistance. By lowering insulin levels, testosterone levels will also decrease, which can improve the signs and symptoms of PCOS.  

Insulin Resistance, PCOS, and Your Long-Term Health   

Understanding whether you can easily switch between burning glucose or fat for energy is an essential indicator of your health. If you assume that everyone’s body has that ability, you’re only looking at one piece of the puzzle. It all depends on how high your insulin levels are.   

High insulin levels can inhibit your body’s ability to switch between burning glucose or fat for energy, impacting overall health. Unchecked insulin resistance can also lead to long-term health issues, including type 2 diabetes, heart disease, and other complex chronic conditions. But with early detection, lifestyle changes, and proper medical guidance, you can effectively manage insulin resistance and PCOS.  

Introducing Lilli Health & the Low Insulin Lifestyle 

Lilli Health is passionate about helping women with PCOS regain control of their health. We focus on lowering insulin levels to improve hormone balance and promote weight loss. What sets us apart is our focus on tackling the root problem – insulin. We provide education, resources, and support to help you understand the ‘why’ behind your symptoms and how to adopt an insulin-lowering lifestyle to effectively manage PCOS and improve your overall health.  

Remember, knowledge is power. Subscribe to our newsletter to stay up to date on everything you need to know about managing your condition through nutrition! 

 

Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder that affects many teenage girls. Although it can be challenging, early detection and education about PCOS, high insulin levels, and insulin resistance are crucial for effective management and long-term health.  

In this blog, we’ll explore the importance of following a low insulin lifestyle and how Lilli Health can help teens navigate their journey with PCOS management, preventing chronic disease, and preserving fertility. Read on to learn everything you need to know about teenage PCOS! 

Early Detection of PCOS and Education 

Signs and symptoms of PCOS can vary from person to person. By being aware of these indicators, both teens and their parents can be vigilant in recognizing potential PCOS-related concerns. Here are some common PCOS symptoms to watch out for: 

• Irregular Periods: Menstrual irregularities, such as infrequent or prolonged periods, can be a sign of PCOS. Tracking menstrual cycles and noting any deviations can be helpful in identifying potential hormonal imbalances.
• Acne and Skin Issues: Teenagers commonly experience acne, but persistent and severe acne on the jawline that does not respond to typical treatments may be linked to PCOS. Skin issues like oiliness, blackheads, and dark patches can also indicate the condition.
• Excessive Hair Growth: PCOS may cause hirsutism, which refers to excessive hair growth in areas such as the face, chest, abdomen, and back.
• Weight Fluctuations: Sudden and unexplained weight gain or difficulties in losing weight despite efforts can be a sign of PCOS.
• Mental Health Disorders: PCOS can have an impact on mental well-being. Anxiety and depression are often associated with the condition, highlighting the importance of considering mental health when assessing PCOS symptoms.

By prioritizing education and PCOS awareness, we can empower teens and their parents to take proactive steps toward timely intervention and support. Regular check-ups with healthcare professionals are crucial in monitoring and managing PCOS. 

Understanding High Insulin Levels 

Understanding insulin and its role in hormonal imbalance is a key aspect of learning about PCOS. In fact, insulin is the underlying culprit behind the symptoms and their severity. Keep reading to understand how insulin contributes to hormonal imbalance and symptoms of PCOS! 

Insulin Resistance and PCOS: The Connection 

Insulin, a hormone responsible for regulating blood sugar levels in our bodies, plays a vital role in our overall health. However, in the case of PCOS, the body may produce excessive amounts of insulin, resulting in higher insulin levels. This phenomenon is known as insulin resistance, which disrupts hormone balance and triggers various PCOS symptoms. This is because when insulin levels are high, the ovaries respond by producing excessive testosterone, leading to symptoms like irregular periods, acne, excessive hair growth, and weight gain. Therefore, the impact of high insulin levels on teens with PCOS is significant. 

Here’s why understanding insulin resistance is crucial for overall health: 

• Weight Gain and Difficulty Losing Weight: Elevated insulin levels contribute to weight gain and make it challenging to shed those extra pounds.
• Chronic Conditions and Long-Term Health Risks: High insulin levels increase the risk of developing chronic conditions like type 2 diabetes and cardiovascular diseases. By adopting a low insulin lifestyle, teens can mitigate these risks as early as possible and promote long-term health.
• Fertility and Reproductive Health: Insulin resistance affects hormonal balance, which can disrupt the menstrual cycle and fertility in teens with PCOS. By managing insulin levels, they can potentially improve their reproductive health and preserve fertility.

In the end, understanding this connection between PCOS diet, insulin, and testosterone is essential for teens with PCOS to effectively manage their symptoms and improve their quality of life. 

The Importance of a Low Insulin Lifestyle 

Following a low insulin lifestyle can significantly reduce insulin and testosterone levels, improve the management of PCOS symptoms, and reduce the risk of associated health complications. Here are a few key aspects of a low insulin lifestyle: 

• Insulin Lowering PCOS Diet: Consuming a diet based on lean proteins, vegetables, fruits, nuts and seeds, and healthy fats and avoiding starches, sugar, and certain types of dairy can help lower insulin levels.
• Regular Exercise: Engaging in regular physical activity improves insulin sensitivity. Incorporating activities such as walking, swimming, or dancing into daily routines can have positive effects on overall health and PCOS management.
• Stress Management: High levels of stress can worsen PCOS symptoms and disrupt hormonal balance. Encouraging stress reduction techniques like mindfulness, meditation, yoga, or engaging in hobbies can help promote emotional well-being and overall health.

How Lilli Health Can Help 

PCOS is a common condition among teenage girls that requires early detection and education. By understanding the impact of high insulin levels and adopting a low insulin lifestyle, teens can effectively manage their PCOS symptoms, reduce the risk of chronic diseases, and preserve their fertility. 

We at Lilli Health understand the unique challenges teens with PCOS face and are committed to providing comprehensive support for their journey. Through innovative resources and a focus on education, Lilli Health aims to empower teens with PCOS and anyone suffering from insulin-related chronic conditions to embrace a low insulin lifestyle. 

Subscribe to our newsletter for more PCOS wellness guides, helpful tips and resources, and personalized info sent to your inbox! Together, we can rewrite the narrative around PCOS management and empower a future of lasting health and wellness. 

The genetics of polycystic ovary syndrome (PCOS) has been a topic of great interest and research in recent years and for good reason. While the exact causes of PCOS are still being explored, emerging evidence suggests that maternal insulin and testosterone levels before and during pregnancy may play a significant role in developing this hormonal disorder.1,2 Understanding the interplay between genetics and maternal hormonal factors can provide valuable insights into the origins of PCOS.  

In this article, we will delve into the fascinating connection between maternal insulin and testosterone levels and the genetic predisposition to PCOS, shedding light on how these factors can influence the development of this complex condition.  

The Intersection of PCOS and Genetic Influence 

PCOS is a hormonal disorder that affects the reproductive system of women. It manifests in a range of symptoms, like irregular menstrual cycles, excessive hair growth, weight gain, acne, and infertility. But did you know that genes may play a significant role in the development of PCOS? While the exact cause of PCOS is still being researched, studies have shown that genetics plays a critical role in its development.3,4 

• Family History: Having a family history of PCOS increases a woman’s risk of developing the condition. Research suggests that if a woman has a first-degree relative, like a mother or sister, with PCOS, her chances of developing the syndrome are significantly higher. How much higher, you ask? It’s estimated that up to 70% of daughters born to women with PCOS will develop PCOS themselves.  
• Genetic Variations: Scientists have identified specific genetic variations associated with PCOS, and the exact variations are shown below.3–5 What this translates to is that these identified changes in particular genes resulted in insulin and hormone imbalances which are the key contributors to PCOS.  
• P450c17: Variations in the P450c17 gene can lead to increased activity of the enzyme, resulting in higher levels of androgen production. 
• INS (Insulin): Variations in the INS gene have been associated with higher insulin levels, which is a common characteristic of PCOS. 
• LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor): Mutations in the LHCGR gene have been linked to excessive production of luteinizing hormone (LH) and elevated androgen levels, both of which are associated with PCOS. 
• FSHR (Follicle-Stimulating Hormone Receptor): Genetic variants in the FSHR gene have been found to influence the development of PCOS by affecting follicle development and hormonal balance. 
• Twin Studies: Studies conducted on twins have provided valuable insights into the genetic component of PCOS. Identical twins, who share 100% of their genes, are more likely to both have PCOS compared to fraternal twins, who share only 50% of their genes. This data suggests that genetic factors strongly influence the development of PCOS. 
• Ethnic Disparities: PCOS can affect women of all ethnic backgrounds. However, studies have found variations in the prevalence of PCOS among different ethnic groups. For example, women of South Asian, Middle Eastern, and Hispanic descent may have a higher risk of developing PCOS compared to women of European or East Asian descent. These findings suggest that genetics and ethnicity might interact to influence PCOS susceptibility.6,7 

Deciphering Genetic Factors in PCOS: Shaping Future Strategies 

Understanding the link between PCOS symptoms and genetics is an ongoing area of research. The presence of a family history of PCOS, specific genetic variations, and the influence of ethnicity all contribute to the development of this complex condition. By unraveling this intricate genetic puzzle, researchers aim to refine diagnosis techniques, aid the development of targeted PCOS treatments, and strengthen preventive strategies. 

PCOS and Genetics: Why a Low Insulin Lifestyle Matters 

Regardless of its cause, it’s widely known that women with PCOS have higher insulin levels compared to women without, regardless of their weight. That’s why it’s crucial for all women with PCOS to follow a low insulin lifestyle. This lifestyle can help alleviate PCOS symptoms, reduce the risk of chronic diseases, and maintain fertility for those wanting to have children.  

At Lilli Health, our vision is to create a paradigm shift in PCOS care, where we focus on the root cause of the symptoms: insulin. By addressing this fundamental aspect head-on, we can pave the way for a new approach to managing PCOS and achieving better outcomes. We’re dedicated to equipping women with the knowledge and tools to regain control over their health and well-being. This journey doesn’t have to be taken alone, and we’re here every step of the way. 

References 

1. FRANKS S, MCCARTHY MI, HARDY K. Development of polycystic ovary syndrome: involvement of genetic and environmental factors. Int J Androl. 2006;29(1):278-285. doi:10.1111/j.1365-2605.2005.00623.x
2. Rosenfield RL, Ehrmann DA. The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited. Endocr Rev. 2016;37(5):467-520. doi:10.1210/er.2015-1104
3. Bruni V, Capozzi A, Lello S. The Role of Genetics, Epigenetics and Lifestyle in Polycystic Ovary Syndrome Development: the State of the Art. Reproductive Sciences. 2022;29(3):668-679. doi:10.1007/s43032-021-00515-4
4. Laven JSE. Follicle Stimulating Hormone Receptor (FSHR) Polymorphisms and Polycystic Ovary Syndrome (PCOS). Front Endocrinol (Lausanne). 2019;10. doi:10.3389/fendo.2019.00023
5. Qin K nan, Rosenfield RL. Role of cytochrome P450c17 in polycystic ovary syndrome. Mol Cell Endocrinol. 1998;145(1-2):111-121. doi:10.1016/S0303-7207(98)00177-4
6. Rodin DA, Bano G, Bland JM, Taylor K, Nussey SS. Polycystic ovaries and associated metabolic abnormalities in Indian subcontinent Asian women. Clin Endocrinol (Oxf). 1998;49(1):91-99. doi:10.1046/j.1365-2265.1998.00492.x
7. Mani H, Davies MJ, Bodicoat DH, et al. Clinical characteristics of polycystic ovary syndrome: investigating differences in White and South Asian women. Clin Endocrinol (Oxf). 2015;83(4):542-549. doi:10.1111/cen.12784